- Increase the size of pagefile.sys to 16 GB or more.
- Open file C:\Users%Username%\AppData\LocalLow\Ice-Pick Lodge\Pathologic 2\Settings\ExternalOptimizationSettings.xml
- In the “ReleaseStrategyIndex” and “DevelopmentStrategyIndex” tags replace 4 with 3.
If this measure doesn’t stop the crashes, you have to revert this change.